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Generic Ventolin inhaler

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The active ingredient of Generic Ventolin inhaler is Salbutamol which is a beta2-adrenomimetic remedy, bronchodilator. Salbutamol possesses a potent bronchodilatory effect, prevents and relieves bronchospasm, increases lung capacity, activates the function of ciliated bronchial epithelium

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Ventolin inhaler 100mcg

The active ingredient of Generic Ventolin inhaler is Salbutamol which is a beta2-adrenomimetic remedy, bronchodilator. Salbutamol possesses a potent bronchodilatory effect, prevents and relieves bronchospasm, increases lung capacity, activates the function of ciliated bronchial epithelium. It is used to treat and prevent all forms of bronchial asthma and reversible airflow obstruction in chronic obstructive pulmonary disease.  

Therapeutic action

Salbutamol is a bronchodilator, b2-adrenomimetice remedy. Salbutamol possesses a potent stimulatory effect on beta 2-adrenergic receptors (localized, particularly in the bronchi, myometrium, blood vessels). 

Salbutamol prevents the release of inflammatory mediators from the mast cells and basophils, in particular, IgE-induced release of histamine, slow reacting substance of anaphylaxis (leukotrienes), PgD2 and other biologically active substances. It eliminates antigen-dependent suppression of mucociliary transport and release of neutrophil chemotactic factor. Salbutamol causes desensitization and reduced the number of beta-blockers including on lymphocytes. Salbutamol exerts potent bronchodilatory effects, preventing or relieving bronchospasm, reduces airway resistance, increases lung capacity.
Generic Ventolin inhaler prevents the development allergen-induced bronchospasm.
Generic Ventolin suppresses the early and late bronchial hyperreactivity.
A positive effect on mucociliary clearance stimulates mucus secretion, activates the function of ciliated epithelium.

Generic Ventolin possesses a tocolytic effect. It lowers the tone and the contractile activity of myometrium.
The medication does not act in beta1-adrenergic receptors of the heart. After inhalation it acts mainly on beta 2-adrenergic receptors in the bronchi, possessing a very weak effect on the beta 2-adrenergic receptors of other organs and tissues. In therapeutic doses, the drug does not exert chronotropic and inotropic effects, have no negative influence on the cardiovascular system, does not cause high blood pressure.
 Generic Ventolin possesses several metabolic effects: reduces potassium blood levels, affects glycogenolysis and insulin release, has a hyperglycemic and the lipolytic effect, increases the risk of acidosis.

After inhalation nearly 10-20% of inhaled dose reach bronchi. Salbutamol binds to plasma proteins by 10%. It is metabolized in the liver and intestinal wall, then is eliminated by kidney in unchanged form or in the form of inactive metabolite within 72 hours with bile.  

Indication

  • Prevention and relief of bronchospasm in all forms of asthma, including nocturnal asthma.
  • Prevention and treatment of reversible airflow obstruction: chronic obstructive bronchitis, chronic obstructive pulmonary disease, emphysema, bronchitis bronchospastic syndrome.   

Contraindications

Reactions of Hypersensitivity 

  • Ischemic heart disease (coronary heart disease)
  • Hypertension 
  • Heart failure 
  • Tachyarrhythmias 
  • Myocarditis 
  • Heart defects 
  • Aortic stenosis 
  • Decompensated diabetes mellitus 
  • Hyperthyroidism
  • Pheochromocytoma
  • Glaucoma 
  • Hepatic or renal insufficiency 
  • Concomitant use with nonselective beta-blockers. 
  • The first trimester of pregnancy, miscarriage threat in I and II trimester of pregnancy. 
  • Breastfeeding

Side effects

The most common Salbutamol side effects include:
Cardiovascular system: possible tachycardia at high doses - decreased blood pressure.
CNS: possible headache, restlessness, anxiety, sleep disturbance.
Allergic reactions: seldom - urticaria, angioedema, bronchospasm, hypotension, collapse. Beware of cases of paradoxical bronchospasm.
Other: muscle tremor, and nausea.  

Interaction

Ventolin inhaler may interact with the following medicines:

  1. Beta-blockers
  2. Diuretics
  3. Digoxin
  4. MAO inhibitors
  5. Tricyclic antidepressants

Storage

Generic Ventolin should be stored in dry place at a room temperature out of reach of children.

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