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Synvisc injection (Hylan GF-20)

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Synvisc is also called as hylan G-F 20 and it an injection given into your knee joints. The active ingredients present in Synvisc are 'hylan A fluid' and 'hylan B gel particles' and they are dissolved in a sterile saline solution. Hylans are cross linked derivatives of sodium hyaluronate which is obtained from the combs of roosters.

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  • 1 pack (3 injections)
  • 3 packs (9 injections)

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Synvisc injection uses

Sodium hyaluronate is a linear polysaccharide which is naturally present in the synovial fluid and protects and lubricates your joints. Synvisc injection is used to treat the inflammation and knee pain in osteoarthritis patients so that their joint mobility can be improved. Synvisc is used when osteoarthritis patients have already tried non-pharmacological therapies such as diet and exercise and pharmacologic therapies such as pain medications but didn’t show any improvement.

Mechanism of action:

The synovial fluid present in the knee joints protects the knee from shocks and acts as a lubricant and cushion. Presence of sodium hyaluronate gives synovial fluid the viscous and rheological properties. Loss of synovial fluid leads to osteoarthritis and knee pain. Synvisc injection functions similar to the synovial fluid due to the presence of hylans (cross linked polymers of sodium hyaluronate) as active ingredients and thereby it gives relief from the knee pain for up to six months.

How to use Synvisc injection:

Synvisc injection is a sterile, non pyrogenic and viscosupplement injection and it is injected into your knee joints by your doctor. You should not try it by yourself. The procedure is called as viscosupplementation because you are supplementing the viscous and rheological properties of Synvisc to protect and lubricate your knees. Skin disinfectants which contain quaternary ammonium salts should not be used to prepare the injection site as ammonium salts can precipitate the hylans. Any extra fluid present in the joint is removed and then Synvisc is injected only into the knee joint but not into any vein or artery or tissue. A total of three injections are given consecutively for three weeks with one injection per week and it provides relief from the knee pain for up to 6 months. The dose of Synvisc varies from patient to patient based on their medical condition and based on their response to the treatment.

Synvisc side effects:

Common side effects which may occur are rashes and bruises at the injected joint, pain, itching and swelling of the injected joint, tiredness, headache, numbness and overall body pains. If any of the side effects worsen or if they are bothering you a lot or if you experience any other side effects, you should immediately discuss with your doctor. Sometimes serious side effects may also occur such as difficulty in breathing, back pain, fever, swelling of the lips and tongue and face, increase in the heart beat, dizziness and closing of your throat. Then you should consult your doctor immediately to seek medical advice.

Synvisc precautions:

Once the syringe is opened, it should be used immediately and it is for single use only. Your doctor should not store it for future use.

If you are allergic to birds or chicken or bird products such as feathers and eggs, you should inform your doctor.

Synvisc is not recommended if you have any joint infections in the knee or skin infections at the injection site or blood circulation problems in your legs.

It is not advisable to use Synvisc injection in pregnant or breast feeding women.

Synvisc should not be used if you are allergic to any other products containing sodium hyaluronate.

After an injection, you should avoid activities such as standing, jogging, weight lifting and tennis for at least two days. Avoid all activities that apply pressure on your joints.

If you are using any other type of medicines along with Synvisc, you should discuss with your doctor.

Care should be taken to take the injection according to the schedule to get best results.

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