Lasix 40mg

Lasix 40mg

Lasix (Furosemide) is a fast-acting diuretic (water pill) derivative of sulfonamide. Is used to treat edema syndrome of various origins, pulmonary edema, renal failure, hypertension, and alsois prescribed for forced diuresis. Lasix original is made by the pharmaceutical company Sanofi Aventis.

Therapeutic action

Lasix containsFurosemide 40mg as an active ingredient. Furosemide is a fast-acting diuretic (medication that increase urine erection) Furosemide - a diuretic rapid-acting derivative of sulfonamide.
Furosemide action mechanism is associated with the blockade of reabsorption of sodium and chloride ions in the Henle's loop. Furosemide also increases the excretion of potassium, calcium and magnesium.
Furosemide acts on convoluted tubules, and this effect is not associated with inhibition of carbonic anhydrase or antialdosterone activity. Furosemide possesses a potent diuretic, natriuretic action.
After oral administration of Furosemide 40mg, therapeutic (diuretic) effect is observed withinthe first hour and reaches its maximum within 1-2 hours. The duration of diuretic effect is 6-8 hours. By possessing diuretic effect Furosemide reduces systemic blood pressure.

After oral administration the bioavailability of Furosemide is 64%. The value of the maximum drug concentration in plasma increases with increasing the dose. The half-life period is nearly 2 hours. Furosemide binds to plasma proteins by 91-99%. Furosemide is metabolized mainly in theglucuronide forms and is excreted with the urine.

Indication

Lasix 40mgis indicated for thetreatment of the following conditions:

• Edematous syndrome of different genesis (chronic heart failure IIB-III stages, liver cirrhosis, syndrome of portal hypertension, edematous ascitic syndrome, nephrotic syndrome);
• Renal failure, nephrotic syndrome, severe hypernatremia, hypercalcemia, and hypermagnesemia;
• Acute left ventricular failure (cardiac asthma, pulmonary edema);
• Cerebral edema;
• Hypertension, including some forms of hypertensive crisis;
• Forced diuresis.

Contraindications

Lasix contraindications include:

• Acute glomerulonephritis
• Severe renal failure
• Oliguria
• Anuria
• Hepatic coma
• Diabetic coma
• Disorders water-salt metabolism: hypokalemia, hyponatremia, hypovolemia, alkalosis
• Gout, hyperuricemia
• Decompensated mitral or aortic stenosis ·
• Hypertrophic cardiomyopathy with obstruction of the outflow tract of left ventricleHypotension
• Myocardial infarction
• Idiosyncrasy (including history of hypersensitivity), furosemide, including other sulfonamides and sulfonamides.

Furosemide cautions

During the first months of treatment it is recommended to control blood pressure, electrolyte levels (especially potassium), CO2, creatinine, urea nitrogen, uric acid, periodic determination of liver enzymes, the level of calcium and magnesium, blood glucose and urine (diabetes).
Prolonged use of Furosemide may cause weakness, fatigue, decreased blood pressure and cardiac output, and excessive diuresis in myocardial infarction. Furosemide should not be taken before treatment with ACE inhibitors

Side effects

Possible furosemide side effects include: Metabolism: hypovolemia, dehydration, hypokalemia, hyponatremia, chloropenia, hypomagnesemia, alkalosis, and in some cases - hypocalcemia, hypercalciuria.

Cardiovascular system: hypotension, including postural, collapse, cardiac arrhythmia, thromboembolism, thrombophlebitis.
Gastrointestinal tract: dry mouth, nausea, vomiting, diarrhea, and in some cases - pancreatitis, liver dysfunction, intrahepatic cholestasis.
Biochemical and blood composition: transient hyperuricemia (aggravation of gout) and an increase of urea and creatinine, and in some cases - impaired glucose tolerance, hyperglycemia and changes in blood picture.
Urinary system: deterioration in obstructive uropathy
Skin reactions: dermatitis.
Sensory organs: vision and hearing problems, paresthesia Other: dizziness, muscle weakness, seizures, confusion, anaphylaxis, exfoliative dermatitis, erythema multiforme, photosensitivity.

Interaction

Furosemide should be used with caution with the following groups of medications:

• Aminoglycoside antibiotic
• Blood pressure medications
• NSAID's
• Digoxin
• Phenytoin
• Salicylates
• Sucralfate
• Chloral hydrate
• Licorice
• Lithium
• Methotrexate
• Corticosteroids
• Cyclosporine

Storage

StoreLasix 40 tablets at dry place at room temperature out of reach of children.