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Lamisil is an antifungal broad-spectrum medical for oral and topical use. It is used for prevention and treatment of mycosis (fungal infection), onychomycosis (fungal nail infections), mycosis of the scalp, fungal infections of the skin – dermatomycosis of legs, feet.

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Lamisil is an antifungal broad-spectrum medical for oral and topical use. It is used for prevention and treatment of mycosis (fungal infection), onychomycosis (fungal nail infections), mycosis of the scalp, fungal infections of the skin - dermatomycosis of legs, feet. Lamisil for external use is effective in multi-colored lichen.

Lamisil is available in the form of tablets Lamisil 250mg tablets, generic and brand drug, and generic Lamisil cream

Pharmacological action

Lamisil is a highly effective antifungal drug for oral or topical use, possessing a wide spectrum of antifungal activity.
Lamisil 250mg (terbinafine) works by specifically inhibiting the biosynthesis of sterols at early stage (sterols) in the fungal cells, leading to a deficiency of ergosterol (ergosterol), following accumulation of intracellular squalene, and finally cell death of the fungus.

Lamisil possesses a broad spectrum of action against fungi causing diseases of the skin, hair and nails, including dermatophytes such as Trichophyton (T. rubrum, T. mentagrophytes, T. verrucosum, T. tonsurans, T. violaceum), Microsporum (M.canis), Epidermophyton floccosum, yeasts and fungi of the genus Candida (C. albicans) and certain dimorphic fungi Pityrosporum (P.orbiculare/Malassezia furfur).

Lamisil has a fungicidal action against dermatophytes, molds and certain dimorphic fungi. The activity of terbinafine against yeasts, depending on their type, may be fungicidal or fungistatic.

Clinical indications

Lamisil is used for prophylaxis and treatment of mycoses (fungal infections):
Lamisil 250mg tablets:

  • Onychomycosis (fungal nail infection) caused by dermatophyte fungi (such as Trichophyton, including T. rubrum, T. mentagrophytes, T. verrucosum, T. violaceum; Microsporum canis and Epidermophyton floccosum);
  • Mycosis of the scalp
  • Fungal infections of the skin: treatment of dermatomycosis of legs, feet, and yeast infections of the skin caused by the genus Candida (including Candida albicans) in cases where the location, severity or prevalence of infection make it desirable to carry the therapy with oral tablets.

Lamisil for topical use

  • Fungal skin infections, including athlete's foot (tinea pedis), groin athlete (tinea cruris), fungal smooth skin of the body (tinea corporis), caused by dermatophytes;
  • Yeast infection of the skin (including diaper rash), mainly those that are called genus Candida (including Candida albicans);
  • Pityriasis versicolor (Pityriasis versicolor), caused by Pityrosporum orbiculare (also known as Malassezia furfur).

Lamisil mode of administration

Lamisil dosage can be indicated only by a health care provider. Do not take the medication without visiting your doctor. Lamisil dosage depends on the severity of the diseases, particular disease treated, patient's age. Lamisil tablets are taken orally usually once daily,

Generic Lamisil cream (terbinafine) is applied topically 1 or 2 times daily.

Adults and children over 12 years before applying the cream should be clean and dry the affected area. A thin layer of Terbinafine cream is applied 1 or 2 times daily on the affected skin and surrounding areas, and is rub lightly. Infections, accompanied by intertrigo (under the breasts, in the interdigital gaps, between the buttocks), the treated area can be covered with gauze, especially at night. With extensive fungal infections of the body is recommended to use cream in tubes of 30 g.

Lamisil contraindications:

Lamisil (terbinafine) is contraindicated for use in the following conditions:

Hypersensitivity to terbinafine or any other components of the drug;

Breastfeeding (for lamisil 250mg tablets);

Pregnancy (for lamisil 250mg tablets) 

Lamisil should be used with caution in:

  • Liver and/or renal failure;
  • Alcoholism
  • Suppression of bone marrow hematopoiesis;
  • Tumor;
  • Metabolic diseases;
  • Occlusive vascular disease of the extremities.

Lamisil during Pregnancy and breastfeeding

In studies conducted in animals, teratogenic terbinafine have been identified. Because clinical experience with terbinafine in pregnant women is limited, it should be used only on strict indications, if a potential therapeutic effect overweights a potential risk of therapy.

Terbinafine is excreted in breast milk. Lamisil tablets 250mg (terbinafine) should not be used during breastfeeding.

Lamisil side effects

Lamisil is generally well tolerated. Side effects are usually mild or moderately expressed and are transient in nature.
Side effects common for Lamisil 250mg tablets include:

Gastrointestinal tract: a sense of stomach fullness, loss of appetite, indigestion, nausea, mild abdominal pain, diarrhea, taste changes, hepatobiliary disorders, cholestasis (rare), hepatic failure (very rare).

Musculoskeletal system: arthralgia, myalgia (often).

Hematological disorders: neutropenia, agranulocytosis, thrombocytopenia.

Allergic and dermatologic reactions: skin rash, urticaria (often), Stevens-Johnson syndrome, toxic epidermal necrolysis, anaphylactoid reaction, alopecia (very rare). If progressive skin rash develops, discontinuation of treatment with Lamisil is required.

Lamisil cream for local use:
Terbinafine cream may cause redness, itching or burning. Discontinuation of treatment because of these adverse effects is rarely required.

In rare cases Lamisil generic cream may cause generalized rash, redness, hives, angioedema (requiring discontinuation of treatment using Lamisil).

Lamisil drug interactions

Lamisil for oral administration should not be combined with the following groups of drugs:

  • Beta blockers
  • Anti-psychotic medications
  • Medications indicated for arrhythmia treatment
  • ADHD drugs
  • Captopril
  • Cimetidine
  • Chloroquinone
  • Dextromethorphan
  • Lomustine
  • Maprotiline
  • Mirtazapine
  • MAO inhibitors
  • Nefazodone
  • Promethazine
  • Some selective serotonin reuptake inhibitors
  • Tamoxifen
  • Tricyclic antidepressants and blood thinners (warfarin)
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