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Keflex generic

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Keflex is a 1st generation semi-synthetic cephalosporin antibiotic for oral administration which possesses a broad spectrum of antibacterial activity. Keflex is indicated for the treatment of infectious diseases of mild and moderate severity:

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Keflex generic

Keflex is a 1st generation semi-synthetic cephalosporin antibiotic for oral administration which possesses a broad spectrum of antibacterial activity. Keflex is indicated for the treatment of infectious diseases of mild and moderate severity: infections of ENT and respiratory system, skin and soft tissue infections, infections of the bones and joints, gonorrhea, gynecological infections, urogenital infection


Generic Keflex contains the same active ingredient as brand medication Cephalexin. Generic medication is therapeutically equivalent to original Keflex, meaning that indications, action mechanism, side effects, contraindications, drug interactions are the same.  Generic medication which is made by GSK is available under different trade names (Phexin).  The difference between generic medication and brand consists in form and shape of tablets, color and sometimes in pharmacokinetic characteristics.

Therapeutic action

Cephalexin belongs to a group of of semisynthetic cephalosporins. Cephalexin exerts bactericidal action against a wide variety of susceptible microorganisms.  The action mechanism is similar to all beta-lactam antibiotics (penicillins and cephalosporins). The main target of Cephalexin action is penicillin-binding bacterial proteins. Cephelexin acts by interfering with the synthesis of peptidoglycan (murein).  Peptidoglycan is a polymer which consists of amino acids and carbohydrates. Murein covers the surface of bacterial plasma membrane and contributes to formation of bacterial cell wall. The blockage of murein synthesis leads to increased permeability of bacterial wall and lysis of the microorganisms.   

Generic Keflex is active against a wide range of gram-positive and gram-negative microorganisms. Most of the following strains are resistant to cephalexin oral:

Gram-positive microorganisms: Staphylococcus; streptococci (enterococci are highly resistant to the drug), pneumococci.

Gram-negative bacteria: E. coli, Salmonellae, Shigellae, Neisseriae, Proteus mirabilis, different strains of Haemophilus mnuenzae and Klebsiella pneumoniae, treponema pallidum.

Cephalexin is active against staphylococci, penicillinase-producing and resistant to penicillin and ampicillin. Cephalexin oral is also active against group A streptococci and pneumonia diplococci resistant to tetracyclines.

Enterococci are resistant to cephalexin. Keflex is ineffective against Pseudomonas aeruginosa, indole-positive strains of Proteus, Mycobacterium tuberculosis, anaerobic microorganisms.

Cephalexin oral is stable in acidic media. Cephalexin antibiotic is quickly and almost completely (95%) is absorbed from the gastrointestinal tract into the blood circulation after oral administration.  Food intake does not affect the absorption of the medication. Therapeutic concentration in the blood remains active from 4-6 hours after administration. The medication is metabolized in the liver and is eliminated with urine in unchanged form. A small amount of cephalexin is excreted with bile. Cephalexin oral does not penetrate the blood-brain barrier.


Keflex antibiotic is indicated for the treatment of infectious diseases caused by sensitive to the medication microorganisms:

  • Upper respiratory tract infections and ENT infections of mild to moderate severity (tonsillitis, pharyngitis, sinusitis, inflammation of the middle ear (otitis media), mastoiditis);
  • Lower respiratory infections of mild to moderate severity (acute and chronic bronchitis, pneumonia, bronchopneumonia, pleural empyema, lung abscess);
  • Urinary tract infections (acute and chronic pyelonephritis, cystitis, urethritis, prostatitis, gonorrhea);
  • Gynecological and obstetric infections, epididymitis;
  • Gonorrhea;
  • Infections of skin, soft tissues, bones and joints (furunculosis, abscess, phlegmon, pyoderma, lymphangitis, acute and chronic osteomyelitis).

Keflex  antibiotic (cephalexin)  is licensed to treat the above infectious diseases only when they are caused by sensitive to the preparation microorganisms. Not all of the microorganisms will respond to the drug. Some of the microorganisms have different resistance patterns in some countries. It means that some of the bacteria strains (usually sensitive to cephalexin) may be resistant in certain countries or areas. The medication is ineffective for the treatment of viral infection (common cold or flu infections).

In certain cases your health care provider may suggest to make some tests to determine if the bacteria are sensitive to amoxicillin. In mild and moderate infections a health care provider may prescribe this drug without prior examinations.

You should take the medicine exactly as prescribed by your doctor. You should completely finish the entire course of treatment even if you start feeling much better. This will help to avoid the development of secondary infections (superinfections). Tablets should be taken with a glass of water swallowing whole. Tablets should not be crashed, split or chewed. It is preferably to take the medicine at the same time each day.


Keflex antibiotic is contraindicated in:

  • Patients with hypersensitivity to Cephalexin, or other beta-lactam antibiotics (penicillins, cephalosporins)
  • Severe kidney diseases (renal failure)
  • Severe kidney diseases (liver cirrhosis)
  • Gastrointestinal obstruction
  • Tumors
  • Pregnancy
  • Breastfeeding (cephalexin can pass through breast milk). Therefore the medication should be avoided in breastfeeding mothers)

Keflex antibiotic special cautions

Patients with known allergy to penicillins and cephalosporin should take the medication with caution because of the possibility of cross-reactions. Cephalexin treatment should be discontinued in case of development of allergic reactions, especially such as anaphylactic shock

The urine of patients receiving cephalexin, may give a false positive reaction to sugar (glycosuria). Coombs' test in patients receiving cephalosporins and penicillins sometimes gives false positive results

The simultaneous use of high doses of cephalosporins and nephrotoxic drugs (aminoglycosides, diuretics) sometimes leads to renal dysfunction.

The dose for patients with impaired renal function should be adjusted.

Avoid alcohol drinking while the treatment

Cephalexin oral may cause you drowsy. That is why it is not recommended to drive or operate any machinery while the treatment.

Side effects

Generic Keflex antibiotic is usually well tolerated and side effects are not common. During clinical trials the following Keflex side effects were observed:

  • Gastrointestinal tract (nausea, vomiting, diarrhea, dry mouth, lack of appetite, abdominal pain);
  • Hemopoietic system: neutropenia, eosinophilia;
  • Superinfection caused by a drug-resistant microorganisms, in particular, mucosal candidiasis (vaginal bacteria overgrowth)
  • Allergic reaction (itching, skin rash, urticaria, angioedema, anaphylactic shock - very rare cases)
  • CNS: headaches, general weakness, dizziness.
  • In very cases Cephalexin may cause increased levels of serum glutamic-oxaloacetic transaminase and serum pyruvic transaminase, jaundice, hepatitis.

These side effects are rare and usually disappear after discontinuing the drug.

Drug interaction

  • Furosemide, ethacrynic acid and and nephrotoxic antibiotics can increase the risk of renal damage
  • Cephalexin enhances the action of blood thinners (warfarin)
  • Salicylates and indomethacin retard the elimination of keflex with urine


Cephalexin tablets should be stored at dry and protected from light place out of reach of children. Store Keflex oral at room temperature. Do not keep the medication in a bathroom.

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