Retin-a cream for Actinic keratosis

Aug.29, 2016

Actuality of problem and its Description

Actinic keratosisActinic keratosis occurs in the sun exposed parts of the skin and it is caused due to the damage to the skin caused by the ultraviolet rays of the sun. The lesion which occurs in this disease are typically crusty in nature and are scaly to feel. On the first sight, many may mistake this for a wart. The region in the body where sunlight gets exposed maximum like the face, lips, scalp and the hand are most vulnerable to getting Actinic keratoses. The color of the lesion may be red and fleshy to press. The color may vary to tan and pink in cases. The size may initially be as small as 3 mm but on the complete growth, it might attain several centimetres. If you roll the fingers over the skin over where the Actinic keratoses is present, it would be felt in his hand. This technique is used by the doctors also to arrive at a decision at the initial stage when the lesion is not easily visible.

In considering the risk factors, we know that the presence of the melanin will be helpful in protecting a person from sunlight. So this is the reason that the fair and blonde colored person is more likely to get the disease when compared to the dark complexion person. Also in the tropical region where the sunlight is greater has more chances of getting this disease as when compared to the temperate region.

This lesion is not unlike a wart, because it can get transformed into a cancer of the skin. Two types of cancer for which it can get transferred include Squamous cell carcinoma and Basal cell carcinoma. Both these cancers are very risky, the squamous cell carcinoma if not treated will spread to the large part of the skin and will undergo metastasis (The word metastasis is a medical term given when the cancer has spread from its original site to distant places through blood. This is particularly risky because then the treatment will be much more difficult and a permanent cure of elimination of the cancer could not be carried out). Though the basal cell carcinoma does not have a metastasis potential akin to squamous cell carcinoma, that basal cell carcinoma can be extremely disfiguring of the face. So the Actinic keratosis needs to taken with a strict caution and appropriate care should be sorted out.

Actinic keratosis Why is Retin A is not good for that problem?

Retin-a contains tretinoin as the active pharmaceutical ingredient and it is a form a vitamin A. The Vitamin A is very beneficial to the skin as it helps in the replenishment of the dead cells and decreases the cohesiveness between the cell. Though it was believed that the topical retinoid works in the case of Actinic keratosis, the research articles have not provided a conclusive evidence. A randomised control trial (research involving patients who are given treatment and placebo randomly), have shown that the topical tretinoin did not reduce the number of lesions of Actinic keratosis in the skin.

Retin a gets converted into the tretinoin inside the body and the tretinoin gets combined with the receptor at the level of cytoplasm and then the combined receptor and the drug migrates to the nucleus and gets attached to the genes (cytoplasm is the part outside the nucleus, the nucleus is the part of the cell containing the genetic material). This brings about the change in the cell.

Conclusion (Treatment results)?

The treatment of the Actinic keratosis, according to the latest evidence include topical 5 FU (5 Fluorouracil, which is a type of chemotherapy agent, topical imiquimod and topical Ingenol.

Though retin a will work in some cases of Actinic keratosis, considering the risk of this condition and the available evidence in the medical literature, please consider your physician for the treatment of actinic keratosis

Retin-a cream for Actinic keratosis
4 (80%) 3 votes
Be Sociable, Share!

Comments are closed.