Jan.13, 2010


Nearly five decades have been passed since piracetam was discovered firstly by scientists at the Belgian pharmaceutical company UCB led by Dr Corneliu E Giurea. The drug was first called  nootropic by dr. Giurea, with the meaning: acting on the mind, due to substances which enhance mental performance, increase blood flow and oxygen to the brain, slow down brain aging, and improve dementia, dyslexia and Alzheimer’s, Down syndrome. One tablet contains an active substance: piracetam. Nootropil was launched clinically by UCB in the early 1970s and remains an important product of that company in Europe.

Nootropil is primarily used in Europe, Asia, South America and the USA. The drug is legal to import into the United Kingdom and the United States for personal use with or without prescription. It became popular as a cognitive enhancement drug among students, who often buy it in a great amount as a powder and then consume it with orange or grapefruit juice to avoid bitter taste. A two week regimen of Nootropil was found to increase verbal memory in healthy college students in a double-blind, placebo-controlled study.

Method of administrations

The dosage regime of Nootropil is prescribed strictly individual that requires a personalized dose for each patient. 1 tablet is taken 3-4 times daily at intervals throughout the day. The dosage can be doubled. The drug should be recommended by your doctor who will suggest to begin with a dosage of 7.2g per day, increasing by 4.8g per day every 3 to 4 days up to a maximum of 20g per day, given in either 2 or 3 divided doses while keeping other antimyoclonic drug unchanged at their optimal dosage.

Nootropil side effects

From the post-marketing experience, the following adverse drug reactions have been noticed:

– Ear and labyrinth disorders: vertigo

– Gastrointestinal disorders: abdominal pain, abdominal pain upper, vomiting, diarrhea, nausea

– Immune system disorders: hypersensitivity, anaphylactoid reaction

– Skin and subcutaneous tissue disorders: dermatitis, pruritus, angioneurotic oedema, rash, urticaria

– Nervous system disorders: somnolence, ataxia, headache, insomnia, epilepsy aggravated,

– Psychiatric disorders: hallucination, agitation, confusion, anxiety

Nootropil contraindications

Nootropil is contra-indicated in patients with severe hepatic and renal impairment and to those under 16 years old.

In clinical studies, at dosages between 15 and 20 grams daily, patients that take nootropil, reported different effects like hyperkinesias, somnolence, nervousness and depression. That is why caution should be exercised by patients intending to drive or use machinery while taking nootropil. It is also contraindicated in patients with hypersensitivity to piracetam and in those with cerebral hemorrhage.nootropil drug

Nootropil pregnancy and lactation

The safety of using this drug during pregnancy has not been sufficiently established. Although studies in animals have not shown teratogenic effects or effects on fertility. On the other hand, in human pregnancy, piracetam is to be avoided during pregnancy. Also piracetam is excreted in human breast milk and is not recommended the usage of  nootropil during breastfeeding or breastfeeding should be discontinued, while having treatment with nootropil. Except under a doctor’s strict supervision and only when the benefits justify possible risks. Otherwise, breastfeeding is not recommended.

Women using the product should be taken appropriate contraceptive precautions.

If you have any allergic reaction, stop using this medication and contact your personal doctor urgently.

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