Posts Archive for August 2010

Diflucan- new word in candidosis treatment.

Aug.02, 2010

Probably there is no women who has never heard about candida infection. Candida infection also known as yeast infection occurs in the case of the fungal overgrowth. Candida albicans is a constant inhabitant  of the mucous lining on the skin, internal and genitals. However, infection occurs in the case of candida disbalance. The most common causes of vaginal candidiasis(thrush) are changes in vagina acidity or hormonal disorders. In this case Candida infection may begin multiply causing pathogenic processes. Women with vaginal thrush complain on vaginal burning or itching , “cottage cheese-like” vaginal discharge with sourish smell are common as well.  However, vaginal thrush is not a doom. Many up-to-date antifungal remedies  are able to manage candida infections without causing severe side effects.

Diflucan manufactured and discovered by Pfizer became one of the most prescribed antifungal medications for the recent years. Diflucan is a brand name of the active ingredient fluconazole. Each Diflucan capsule contains 50,  100, 150 and 200mg of fluconazole. Each pack with 50-100 mg of fluconazole contains 7 or 28 capsules, however packs with 150-200 mg contain only 1 capsule. Besides active ingredient, capsules involve additional neutral substances- lactose, corn starch, colloidal silicon dioxid, megnesium stearatis, Diflucan is also available in the form of powder for suspension preparation.

Therapeutic action of Diflucan is determined by fluconazole that acts on fungal cells, increasing cellular permeability and disturbing the growth and replication. Fluconazole penetrates into all biological fluids, possessing a broad spectrum of antimycotic activity. The medication is metabolized in the liver and excreted with urine, nearly 80% in native state. Good pharmacokinetic indexes of Diflucan determine a broad spectrum of clinical use. Diflucan is effective in:

  • Cryptococcosis
  • Generalized candididasis
  • Candidosis of the mucous lining
  • Genital candidosis
  • Mycosis of the skin
  • Deep endemic mycosis

In addition, Diflucan can be used in HIV, tumor diseases especially for prophylaxis while radio and chemotherapy.  Diflucan is effective  in children, however only under the doctors supervision.

The dosage regimen in children and adults is usually based on age and severity of the disease. In most cases of  vaginal thrush, only single dose of Diglucan is effective. The drug can be used before, after and during meal intake. It’s recommended to take Diflucan with a small amount of water. Withdrawal of alcoholic beverages is strongly required.

Fluconazole is usually well-tolerated. In rare cases patients complain on gastrointestinal manifestations: nausea, stomach pain, diarrhea and meteorism. Some patients experienced skin rash,  headache.

In conclusion it’s necessary to underline that Diflucan is Rx medication meaning that is available only with a prescription. Do not treat yourself on your own initiative. Appropriate application of Diflucan according to doctor’s prescription will lead to desired therapeutic effect and lack of significant side effects.